منابع مشابه
Outer retinal corrugations in age-related macular degeneration.
IMPORTANCE Optical coherence tomography (OCT) abnormalities of age-related macular degeneration (AMD) have not been fully characterized because of the complex morphology and a lack of correlative histologic studies. Expansion of our ability to interpret increasing attributes brings us closer to the goal of in vivo histologic analysis of the eye by OCT. OBJECTIVE To describe a new outer retina...
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Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic glutamatergic drive of the sensory retina and, perhaps more importantly, removes coordinated Ca++-coupled signaling to the neural retina. As in other central nervous system degenerations, deafferentation act...
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Mutations in the photoreceptor protein peripherin-2 (also known as RDS) cause severe retinal degeneration. RDS and its homolog ROM-1 (rod outer segment protein 1) are synthesized in the inner segment and then trafficked into the outer segment where they function in tetramers and covalently linked larger complexes. Our goal is to identify binding partners of RDS and ROM-1 that may be involved in...
متن کاملOUTER RETINAL TUBULATION IN ADVANCED AGE-RELATED MACULAR DEGENERATION: Optical Coherence Tomographic Findings Correspond to Histology.
PURPOSE To compare optical coherence tomography (OCT) and histology of outer retinal tubulation (ORT) secondary to advanced age-related macular degeneration in patients and in postmortem specimens, with particular attention to the basis of the hyperreflective border of ORT. METHOD A private referral practice (imaging) and an academic research laboratory (histology) collaborated on two retrosp...
متن کاملClinicopathological correlation of outer retinal tubulation in age-related macular degeneration.
Wilmette, IL—Pediatric Eye Associates (3/1):Deborah R. Fishman (I), JoAnn Spieker (C), Aliza Julian (E); Portland, OR—Casey Eye Institute (3/0):Daniel J. Karr (I), Allison I. Summers (I), Paula K. Rauch (C), YelenaM. Bubnoz (E), Albert Romo (E); Columbus, OH—The Ohio State University (3/0):Marjean T. Kulp (I), Freda D. Dallas (C); Portland, OR—Pacific University College of Optometry (3/2): Rich...
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ژورنال
عنوان ژورنال: Archives of Ophthalmology
سال: 2004
ISSN: 0003-9950
DOI: 10.1001/archopht.122.4.587